In situ Formed Implants, Based on PLGA and Eudragit Blends, for Novel Florfenicol Controlled Release Formulations

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Novel Carbopol – Wax Blends for Controlled Release Oral Dosage Forms

ii ACKNOWLEDGEMENTS I would like to thank my major professor, Dr. Atul J. Shukla for his valuable support and guidance. I would also like to thank my committee members, Dr. for their valuable suggestions and guidance. I would also like to thank my present lab colleagues Dr. for their guidance and help. I thank my parents, wife and sister for supporting me at all times. My success has always bee...

Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit

Accepted September 16, 2013 Alginate vehicles are capable of forming a gel matrix in situ when they come into contact with gastric medium in the presence of calcium ions. However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. The aim of this work was to develop modified in situ gelling alginate formulations capable of sustaining dextromethorpha...

Study of Release Kinetics of Dexamethasone from Biodegradable Plga In-situ Implants

The primary objective of this study is to evaluate the effect of drug loading and the effect of excipients on the release pattern of Dexamethasone Sodium Phosphate from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in dimethyl sulfoxide (DMSO). Then the drug with excipients or without excipients was added to it....

Bioerodable PLGA-Based Microparticles for Producing Sustained-Release Drug Formulations and Strategies for Improving Drug Loading

Poly(lactic-co-glycolic acid) (PLGA) is the most widely used biomaterial for microencapsulation and prolonged delivery of therapeutic drugs, proteins and antigens. PLGA has excellent biodegradability and biocompatibility and is generally recognized as safe by international regulatory agencies including the United States Food and Drug Administration and the European Medicines Agency. The physico...